Chinese Mid-Autumn Festival, National Day, and Chung Yeung Festival -Holiday Announcement 
Thank you for your support for the service in HKLAB.
The cut off time of sample collection will not be later than 13:00 on the Day following the Chinese Mid-Autumn Festival (Sept 14th, 2019), National Day (Oct 1st, 2019), and Chung Yeung Festival (Oct 7th, 2019)
Further, the issue of Manlix Test reports may be postponed due to the holiday reason.
Please do not hesitate to contact us if you have queries.

Hong Kong Laboratory Co., Ltd
29 August 2019

 

HKLAB - Technologies
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    High accuracy can be achieved by utilizing automatic instrumentation, which minimizes the contamination and increase the traceability for all the samples. This is one of our goals.  

Technologies

 

 

 

 Molecular Diagnostics

The rise of molecular biology has significantly revolutionized the clinical diagnosis and treatment of diseases, since modern molecular diagnostics can detect the presence of genetic materials (DNA & RNA) or proteins associated with a specific health condition or disease to discover its mechanisms at molecular level rather than a traditional cellular level. Therefore, scientists and technologists could assess and manage the individuals' health in a more accurate way.

 

 

 
Molecular Biology
  1. What is the relationship between DNA, Gene and Chromosomes?

    DNA or deoxyribonucleic acid is a long two-stranded molecule that contains our unique genetic code. To store this important genetic material, DNA molecules are tightly packed around proteins called histones to make structures called chromosomes. Human beings have 23 pairs of chromosomes in every cell, of which the sex chromosomes determine whether you are a male (XY) or a female (XX). While gene is just fragment of one specific DNA that codes for a specific protein. Human beings have 20,000 to 25,000 genes. These genes account for only about 3 percent of our DNA. The function of the remaining 97 percent is still not clear. 

     
  2. The importance of DNA Extraction 

    The first step of almost all molecular diagnostics is to extract DNA from samples. Nowadays, increasing automation is enabling sophisticated extraction to be performed faster and more precisely. Our lab is equipped with the cutting-edge instruments to make full automation of the process in order to ensure the accuracy of experimental results. 
     
  3. If there are fewer target genes in the sample, how can it be tested accurately?



    One of the essential methods applied in molecular diagnostics is polymerase chain reaction (PCR), the process of making more than thousand copies of the DNA until they can be measured, which is most widely used and is considered work horse in molecular diagnostics. The delicate DNA amplification machine in our lab is able to monitor the whole process of amplification and can successfully generate precise results through the computer calculations. 
     
  4. How to utilize the advanced molecular diagnostics to manage individuals' health condition?

    Non-Invasive Prenatal Test (NIPT): The test requires cell free fetal DNA from maternal blood analyzed with NGS technique (Next Generation Sequencing) to screen for any abnormal chromosome such as Down Syndrome in the fetus, instead of the conventional invasive method of Karyotype. 


Cancer: Since certain molecular diagnostic tests can provide prognostic information about cancer in its early stages, this helps to determine whether aggressive is necessary to give early management. In addition, analyzing the molecular mechanism of cancer cells enables physicians to classify the cancers and choose the best therapy for their patients. 

Personalized Medicine: Since the result information of patients' Single Nucleotide Polymorphisms (SNP) detected by NGS technique, can help predict how quick that the patients can metabolize the particular drugs, therefore information of polymorphisms are useful for physicians to find out if the drugs are effective to that patient.

 

 

Automated Workflow

Full automation of our complete workflow contributes greatly to minimize the experimental contamination and then improve significantly the accuracy and efficiency of tests. 
 

  • Sample Extraction and Purification

    Molecular diagnostic testing of patient samples starts with sample extraction and purification. Both manual and automated extractions are possible. Instead of manual extraction, HKLAB utilizes the international advanced instrument of QIAGEN® to enable the fully automated purification once the samples have been loaded into the machine, which gives no chance to contamination caused by manual operation and ensures the purity and yield of the target nucleic acid finally isolated. Therefore, the downstream experiment could begin with the most pure nucleic acid and show the reliable results.


     
     

  • PCR & Liquid Handling Setup

    In order to eliminate manual pipetting error and cross-contamination resulting from human error, HKLAB has equipped us with the PCR liquid handling instrument of QIAGEN® to perform automated assay setup, which delivers rapid and high-precision PCR experiment and standardize results. Hence, accurate experimental results could be achieved with high efficiency. Of course, the instrument would be maintained periodically by experienced technicians to ensure the smooth performance without error.


     

 
 
 

 

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Hotline : (+852) 2350-6338   (Enquiry)
Fax : (+852) 3468-3495
E-mail : info@laboratory.hk
Address : Unit F,8/F,Valiant Industrial Centre,2-12 Au Pui Wan Street,Fo Tan,N.T.,Hong Kong
Office Hours : Monday - Saturday 9:30-13:00 & 14:30-18:00
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